Will Ferrell

Sherlock Holmes

John C. Reilly

Dr. John Watson

Rebecca Hall

Dr. Grace Hart

Kelly Macdonald

Mrs. Martha Hudson

Rob Brydon

Inspector Lestrade

Lauren Lapkus

Millie

Pam Ferris

Queen Victoria

Ralph Fiennes

Prof. James Moriarty / Jacob Musgrave

Adam Scherr

Brawn

Kieran O'Brien

PC Smalls

Noah Jupe

Doxy

Bella Ramsey

Flotsam